Table I.
Association analyses between the expression levels of CD147 and MMP-2 and the clinicopathological characteristics of endometrioid endometrial cancer.
CD147 expression | MMP-2 expression | ||||||||
---|---|---|---|---|---|---|---|---|---|
Clinicopathological variable | Patients, n | Low, n | High, n | χ2 | P-value | Low, n | High, n | χ2 | P-value |
All cases | 107 | 59 | 48 | 58 | 49 | ||||
Age, years | 6.24 | 0.009 | 9.67 | 0.002 | |||||
>60 | 46 | 19 | 27 | 17 | 29 | ||||
≤60 | 61 | 40 | 21 | 41 | 20 | ||||
FIGO stage | 0.445 | 0.505 | 7.316 | 0.007 | |||||
Low (I/II) | 77 | 44 | 33 | 48 | 29 | ||||
High (III/IV) | 30 | 15 | 15 | 10 | 20 | ||||
Histological grade | 1.611 | 0.204 | 6.669 | 0.010 | |||||
Low (G1 or 2) | 84 | 49 | 35 | 51 | 33 | ||||
High (G3) | 23 | 10 | 13 | 7 | 16 | ||||
Lymph node metastasis | 6.801 | 0.009 | 2.668 | 0.102 | |||||
Negative | 74 | 47 | 27 | 44 | 30 | ||||
Positive | 33 | 12 | 21 | 14 | 19 | ||||
Depth of myometrial invasion | 3.394 | 0.065 | 4.348 | 0.037 | |||||
<50% | 66 | 41 | 25 | 41 | 25 | ||||
≥50% | 41 | 18 | 23 | 17 | 24 | ||||
ER expression | 10.025 | 0.002 | 3.128 | 0.077 | |||||
Low | 60 | 25 | 35 | 28 | 32 | ||||
High | 47 | 34 | 13 | 30 | 17 | ||||
PR expression | 2.155 | 0.142 | 7.962 | 0.005 | |||||
Low | 54 | 26 | 28 | 22 | 32 | ||||
High | 53 | 33 | 20 | 36 | 17 |
FIGO, International Federation of Gynecology and Obstetrics; ER, estrogen receptor; PR, progesterone receptor; CD147, extracellular matrix metalloproteinase inducer; MMP-2, matrix metalloproteinase-2.