Table 2.
Most significant pathways and networks identified by IPA of genes showing significant (p < 0.001) promoter hypermethylation (A) and hypomethylation (B) of the schizophrenia affected vs. healthy monozygotic twins in twin pair 2
| A) | ||
|---|---|---|
| Canonical Pathways | P-value | Ratioa |
| Triacylglycerol Biosynthesis | 2.94E-03 | 4/33 (0.121) |
| Phosphatidylglycerol Biosynthesis II | 3.39E-03 | 3/17 (0.176) |
| Molecular and Cellular Functions | ||
| Gene Expression | 5.79E-06–3.62E-02 | 53 |
| Cellular Movement | 9.84E-04–4.83E-02 | 19 |
| Molecular transport and protein trafficking | 4.01E-03–4.39E-03 | 16 |
| Diseases and disorders | ||
| Developmental disorder | 9.84E-04–4.10E-02 | 36 |
| Hereditary disorder | 9.84E-04–3.77E-02 | 46 |
| Most Significant Networks | # of molecules | |
| Cell Death and Survival, Cellular Growth | 47 | |
| Cellular Movement, Immune Cell Trafficking | 45 | |
| B) | ||
| Canonical Pathways | P-value | Ratioa |
| Glutamate Receptor Signaling | 1.05E-02 | 4/56 (0.071) |
| CREB Signalling in Neurons | 1.53E-02 | 7/169 (0.041) |
| Molecular and Cellular Functions | ||
| Cell Signalling | 4.34E-06–4.51E-02 | 18 |
| Nucleic Acid Metabolism | 4.34E-06–4.51E-02 | 16 |
| Small Molecular Biochemistry | 4.34E-06–4.51E-02 | 29 |
| Diseases and disorders | ||
| Cell death and survival | 3.55E-06–4.76E-02 | 141 |
| Inflammatory disease | 3.35E-03–4.59E-02 | 18 |
| Most Significant Networks | # of molecules | |
| Cellular Movement, Immune Cell Trafficking | 64 | |
| Cell Death and Survival, Cell Cycle, Embryonic Development | 45 | |
| Cellular Movement, Cellular Growth and Proliferation, cell morphology | 44 | |
aThe number of molecules that reach the threshold of significant methylation difference between twins
(Peak score > =3.1)