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. 2014 Sep 1;34(26):3357–3368. doi: 10.1038/onc.2014.269

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Murine neuroblastomas recapitulate genomic aberrations of human neuroblastomas. (a) Mouse karyotype overview of all genomic imbalances detected in 13 murine neuroblastomas (green bars: gained regions, red bars: lost regions). (b) Partial ratio plot for the mouse chromosome 6 region encompassing the ROSA26 amplicon in tumor 9 (right) and copy number of the MYCN transgene in 13 tumors from heterozygous LSL-MYCN;Dbh-iCre mice (+/−), as assessed by qPCR (insert left). Bars represent mice with normal chromosome 6 copy number (white), with whole chromosome 6 gain (black) and with focal chromosome 6 amplification (striped). (c) Tumor/control ratio plot for mouse chromosome 11 in tumor 9 showing partial chromosome 11q gain, corresponding to gain of almost the entire human chromosome 17.