Figure 3.

Course of infection in an HIV transmission pair. a Longitudinal plasma HIV RNA viral load and CD4+ T cell counts for the donor over 60 months of follow up. Grey shading represents the period during which the subject received antiretroviral therapy (ART) following decline of the CD4+ T cell count to <350cells/mm³ [58]. The horizontal dotted line represents the limit of detection (LOD) of the viral load assay (40 copies/ml). Arrows indicate the time of sampling for ultra-deep sequencing. b Longitudinal plasma HIV RNA viral load and CD4+ T cell counts for the recipient showing disease progression over 54 months of follow up. Grey shading represents the periods during which the subject received antiretroviral therapy (ART), initially as peri-partum prophylaxis and subsequently following decline of the CD4+ T cell count to 350cells/mm³ at 55 months post-diagnosis [58]. The horizontal dotted line represents the limit of detection (LOD) of the viral load assay (40 copies/ml). Arrows indicate the time of sampling for ultra-deep sequencing.