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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Hypertension. 2015 Apr 27;65(6):1288–1297. doi: 10.1161/HYPERTENSIONAHA.115.05290

Figure 3.

Figure 3

A, Gene transfer of neuronal nitric oxide synthase adaptor protein (CAPON; Ad.PRSx8-mCherry/CAPON) significantly increased NOS activity in stellate ganglia from spontaneously hypertensive rat (SHR) when compared with the empty vector (Ad.PRSx8-mCherry), control (n=3 measures, with each measure from tissue pooled from 2 animals). The specific nNOS inhibitor, S2, N-[(4S)-4-Amino-5-[(2-aminoetyl) amino] pentyl]-N′-nitroguanidine (AAAN, 10 μmol/L) normalized the difference in NOS activity after transduction with CAPON (n=3 measures) or the empty vector control (n=3 measures; *P<0.05, ANOVA). B, cGMP concentration in SHR stellate ganglia tissue was significantly enhanced by Ad.PRSx8-mCherry/CAPON transduction (n=10) when compared with empty controls (Ad.PRSx8-mCherry; n=10; *P<0.05, unpaired t test).