Table 2.
MIC of antibiotics in combination with extracts at sub-inhibitory concentrations against P. aeruginosa PA124
| Plant extracts a | Antibiotcs b | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CHL | AMP | ERY | KAN | STR | TET | CIP | NFX | ||
| ATB Alone | 64 | - | 128 | 128 | 64 | 16 | 32 | 128 | |
| AGR | MIC/2 | 64(1) | - (NA) | 128(1) | 16(2) | 32(2) | 16(1) | 32(1) | 128(1) |
| MIC/4 | 64(1) | - (NA) | 128(1) | 16(2) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/8 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/16 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| AGB | MIC/2 | 64(1) | - (NA) | 128(1) | 128(1) | 32(2) | 8(2) | 32(1) | 128(1) |
| MIC/4 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/8 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/16 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| AGL | MIC/2 | 64(1) | - (NA) | 128(1) | 16(2) | 64(1) | 16(1) | 32(1) | 128(1) |
| MIC/4 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/8 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/16 | 64(1) | - (NA) | 128(1) | 128(1) | 64(1) | 16(1) | 32(1) | 128(1) | |
| AGF | MIC/2 | 32(2) | - (NA) | 128(1) | 64(2) | 32(2) | 16(1) | 32(1) | 128(1) |
| MIC/4 | 64(1) | - (NA) | 128(1) | 64(2) | 32(2) | 16(1) | 32(1) | 128(1) | |
| MIC/8 | 64(1) | - (NA) | 128(1) | 64(2) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/16 | 64(1) | - (NA) | 128(1) | 64(2) | 64(1) | 16(1) | 32(1) | 128(1) | |
| AGFl | MIC/2 | 64(1) | - (NA) | 128(1) | 64(2) | 64(1) | 8(2) | 32(1) | 128(1) |
| MIC/4 | 64(1) | - (NA) | 128(1) | 64(2) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/8 | 64(1) | - (NA) | 128(1) | 64(2) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/16 | 64(1) | - (NA) | 128(1) | 128 | 64(1) | 16(1) | 32(1) | 128(1) | |
| GQW | MIC/2 | 64(1) | - (NA) | 128(1) | 64(2) | 32(2) | 16(1) | 32(1) | 128(1) |
| MIC/4 | 64(1) | - (NA) | 128(1) | 64(2) | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/8 | 64(1) | - (NA) | 128(1) | 128 | 64(1) | 16(1) | 32(1) | 128(1) | |
| MIC/16 | 64(1) | - (NA) | 256(0.5) | 128 | 64(1) | 16(1) | 32(1) | 128(1) | |
| CML | MIC/2 | 32(2) | - (NA) | 64(2) | 64(2) | 32(2) | 4(4) | 16(2) | 16(2) |
| MIC/4 | 32(2) | - (NA) | 64(2) | 64(2) | 32(2) | 4(4) | 16(2) | 16(2) | |
| MIC/8 | 64(1) | - (NA) | 128(−) | 64(2) | 64(1) | 8(2) | 32(1) | 128(1) | |
| MIC/16 | 641) | - (NA) | 128(−) | 64(2) | 64(1) | 8(2) | 32(1) | 128(1) | |
a : Plan extracts: (AGFl : Allanblackia gabonensis Flowers, AGF : Allanblackia gabonensis Fruits, AGL: Allanblackia gabonensis Leaves, AGB: Allanblackia gabonensis Stem barks, AGR: Allanblackia gabonensis Root barks, GQW: Gladiolus quartinianus Whole plant, CML: Combretum molle Leaves); b : Antibiotics (TET: tetracycline, KAN: kanamycin, STR: streptomycin, ERY: erythromycin, CHL: chloramphenicol, NFX: norfloxacin, CIP: ciprofloxacin, AMP: ampicillin); − : MIC not detected at up to 256 μg/mL; (): Modulation factor or gain of activity; NA: Not applicable, Values in bold represent the modulation factor ≥ 2, the selected extracts and its concentrations to be used on others MDR bacteria