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Evaluation of cardiotoxicity.
Notes: Mice were intravenously injected with DOX, LP–DOX complexes, and virosomes containing DOX (as DOX 5 mg/kg) two times per week for 3 weeks. Myocardial samples were isolated from the left ventricle. Mitochondria (M) and myofibril (My) structures were shown in myocardium electron micrographs. Scale bars represent 1 μm.
Abbreviations: DOX, doxorubicin; LP, liposome.
