Table 2.
Methylation Frequency for Four Genes in Samples of HCC and LC Cases
| Gene | Tumor (n=34) (%) | Nontumor (n=34) (%) | HCC plasma (n=31) (%) | LC tissue (n=10) (%) | LC plasma (n=10) (%) | Tumor vs. nontumor, p-value | Tumor vs. LC, p-value | HCC plasma vs. LC plasma p-value |
|---|---|---|---|---|---|---|---|---|
| ELF | 22 (64.70) | 13 (38.24) | 18 (58.06) | 3 (30) | 2 (20) | 0.029 | 0.113 | 0.084 |
| RASSF1A | 32 (94.12) | 25 (73.52) | 16 (51.61) | 8 (80.0) | 2 (20) | 0.021 | 0.460 | 0.244 |
| p16 | 25 (73.52) | 17 (50) | 13 (41.94) | 7 (70) | 3 (30) | 0.046 | 1.000 | 0.919 |
| GSTP1 | 23 (67.65) | 14 (41.17) | 12 (38.70) | 6 (60) | 4 (40) | 0.028 | 0.945 | 1.000 |
p-Value, analyzed by χ2 test.
HCC, hepatocellular carcinoma; LC, liver cirrhosis.