Table 1.
Tumor Incidence and Burden at End Point for Each Brain Metastasis Model
| SUM190-BR3 |
JIMT-1-BR3 |
231-BR-HER2 |
||||||
|---|---|---|---|---|---|---|---|---|
| 500,000 Cells Injected |
175,000 Cells Injected |
100,000 Cells Injected |
||||||
| Mouse ID | # of Tumors | Total Tumor Volume (mm3) | Mouse ID | # of Tumors | Total Tumor Volume (mm3) | Mouse ID | # of Tumors | Total Tumor Volume (mm3) |
| 1 | 1 | 0.0913 | 9 | 28 | 5.3570 | 1 | 9 | 1.6861 |
| 7 | 1 | 0.1697 | 10 | 26 | 7.5645 | 2 | 11 | 10.7690 |
| 8 | 2 | 0.6510 | 12 | 20 | 2.8284 | 3 | 54 | 30.9075 |
| 19 | 1 | 0.1665 | 13 | 5 | 1.4802 | 4 | 21 | 7.2567 |
| 15 | 8 | 1.0904 | 5 | 7 | 4.6846 | |||
| 17 | 4 | 0.6696 | ||||||
| Mean | 1.25 | 0.2696 | Mean | 15.17 | 3.1650 | Mean | 20.40 | 11.06 |
| SD | ± 0.50 | 0.2568 | SD | ± 10.82 | 2.7440 | SD | ± 19.54 | 11.59 |
Number of tumors and total tumor volume are shown for each mouse, as well as average values and standard deviations within each model. Overall, SUM190-BR3 mice have the smallest tumor burden, and MDA-MB-231-BR-HER2 mice have the largest, in terms of both number of tumors and total tumor volume.