Fig 5. Global myocardial blood flow (MBF) at rest or stress (A) and myocardial flow reserve (MFR) (B) were comparable in diabetic (open bars) and control (black bars) animals.

Wire-myograph results of distal parts of the left anterior descending artery showing different relaxation responses to bradykinin and sodium nitroprusside (SNP) of atherosclerotic and healthy animal and between small ~150 μm (C, E, G) and larger ~300 μm (D, F, H) vessel size. The contribution of vasodilator NO to bradykinin-evoked relaxation was determined by the inhibitory effect of a nitric oxide synthase (NOS) inhibitor. * P < 0.05 control versus diabetic at given concentration.