Table II. Basal Activation of T-bet and NF-κB.

Treatment	Patient No.	T-bet	NF-κB	TCR	Abnormal Phenotype
CML no treatment	1	−	+	−	None
Dasatinib	1	+	+	+	LGL-like
	2	−	+	+	LGL-like
	12	−	−	−	None
	13	−	+	−	NK-T Pheno
Imatinib	1	−	+	−	None
	4	−	−	+	Unknown
Nilotinib	1	+	+	+	LGL-like
	2	−	−	+	None

Transcription factors T-bet and NF-κB were checked to determine if they were constitutively active in the CD8+ population of a representative subset of TKI-treated patients. A culmination of two experiments showing that only TCR positive and large granular lymphocyte (LGL)-like phenotype indicated above normal levels of T-bet and NF-κB.