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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: AIDS. 2015 Jun 1;29(9):1035–1044. doi: 10.1097/QAD.0000000000000648

Table 2.

Summary of significant associations between disease severity and DTI measures among youth with PHIV.

White Matter Tract Disease severity measure DTI parameter Hemisphere r value p value
Forceps minor (Fminor) Nadir CD4% AD n/a -0.39 p<0.05
Forceps minor (Fminor) Nadir CD4% MD n/a 0.54 p<0.001
Inferior fronto-occipital fasciculus (IFO) Peak viral load FA right -0.45 p<0.01
Inferior longitudinal fasciculus (ILF) Peak viral load Streamline count left 0.30 p=0.05
Uncinate fasciculus (UNC) Peak viral load FA left -0.56 p<0.001

Associations between disease severity markers and FA, AD, MD and number of streamlines among youth with PHIV (adjusted p values following 1,000 permutations are reported). Pearson r represents directionality of association, for both the left and right hemispheres. There were no significant associations between Recent CD4% and DTI parameters. FA: fractional anisotropy; DTI: diffusion tensor imaging. AD: axial diffusivity; MD: mean diffusivity.