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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Pediatr Res. 2013 May 31;74(2):141–147. doi: 10.1038/pr.2013.85

Figure 2.

Figure 2

Serum antibody responses to vaccination. (A) Significantly different serum immunoglobulin concentrations post-vaccination as measured by Luminex assay (IgG2b: C57Bl/6 = 3.88×106 ng/ml (SEM, 2,072,000), hemizygous = 350,000 ng/ml (SEM, 92,000), SCD = 635,000 ng/ml (SEM, 162,000); p<0.01) (IgM: C57Bl/6 = 1.44×106 ng/ml (SEM, 244,000), hemizygous = 497,000 ng/ml (SEM, 59,000), SCD = 570,000 ng/ml (SEM, 75,000); p<0.001). (B) Pre- versus postvaccination fold-change in significantly different serum immunoglobulins postvaccination. (C) Serum concentrations of OVA-specific IgE antibodies as measured by ELISA (C57Bl/6 = 242 ng/ml (SEM, 48), hemizygous = 1854 ng/ml (SEM, 758), SCD = 2452 ng/ml (SEM, 754); p<0.05). Bars represent mean levels +/− standard error of the mean. Significant differences were determined by one-way analysis of variance and pairwise comparisons were conducted using the Dunnett’s post-hoc test with SCD serving as the control group. Black bars = C57Bl/6; grey bars = hemizygous; white bars = SCD. *p<0.05, **p<0.01.