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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Chem Rev. 2004 Feb;104(2):825–848. doi: 10.1021/cr020619e

Table 5.

Kinetic Parameters for Ligand Exchange from Low-Spin Nitrile Hydratase Model Compounds

koff (s−1) kon (M−1 s−1) ΔH╪ (kcal mol−1)
[Fe(III)(S2Me2N3(Et,Pr))(MeCN)]+ (40)a 8.50(2) × 104 @ 7.1 ± 0.8
[Fe(III)(S2Me2N3 (Et,Pr))(PhCN)]+ a 3.27(2) × 104 @ 4.9 ± 0.8
[Fe(III)(S2Me2N3(Et,Pr))(iPrCN]+ a 3.27(2) × 104 @ 5.4 ± 0.6
[Fe(III)(SMe2N4(tren))(MeCN)]2+ a 1.25(1) × 101 @
[Co(III)(S2Me2N3(Pr,Pr))(N3)] (23-N3)b 2.1(5) × 10−2 1.6 ± 9.5
[Co(III)(S2Me2N3(Pr,Pr))(SCN)] (23-SCN)b 7.22(4) × 10−1 (3.6 ± 0.6) × 101
[Co(III)(NH3)5(H2O)]3+ 5.7 × 10−6 c
[Fe(III)(S2Me2N3(Pr,Pr))(N3)] (28)b 1.4(5) × 10−1 2.5 ± 0.3
a

Shearer, J.; Jackson, H. L.; Schweitzer, D.; Rittenberg, D. K.; Leavy, T. M.; Kaminsky, W.; Scarrow, R. C.; Kovacs, J. A. J. Am. Chem. Soc. 2002, 124, 11417.

b

Shearer, J.; Kung, I. Y.; Lovell, S.; Kaminsky, W.; Kovacs, J. A. J. Am. Chem. Soc. 2001, 123, 463.

c

Gonzalez, G.; Moullet, B.; Martinez, M.; Merbach, A. E. Inorg. Chem. 1994, 33, 2330.

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