Table III.

Response (healed or improved) to treatment from visit 2 (day 3) to visit 5 (day 14): FAS and PP.

	FAS		PP
Response to treatment	BNO 1016 480 mg (n = 294)	Placebo (n = 295)	BNO 1016 480 mg (n = 213)	Placebo (n = 220)
Visit 2 (day 3)	57.8%	55.6%	60.6%	55.9%
	p value*† = 0.5455		p value*† = 0.3243
Visit 3 (day 7)	86.1%	78.0%	89.7%	76.4
	p value*† = 0.0076		p value*† = 0.0002
Visit 4 (day 10)	90.8%	80.7%	95.8%	80.5%
	p value*† = 0.0002		p value*† < 0.0001
Visit 5 (day 14)	93.2%	85.1%	94.8%	83.6%
	p value*† = 0.0016		p value*† = 0.0002

*Two-sided; alpha = 0.05.

^†Cochran–Mantel–Haenszel test.

FAS, full analysis set; PP, per-protocol population.