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. 2015 Jul 2;11:143. doi: 10.1186/s12917-015-0458-x

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© Permuy et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Box plot comparing the scores obtained by the different experimental groups for qualitative microscopic grading of cartilage and synovial alterations (decalcified samples). Outside values were defined as the values that were smaller than the lower quartile minus 1.5 times the interquartile range or larger than the upper quartile plus 1.5 times the interquartile range (inner fences). CTRL: healthy + placebo; OA: osteoarthritis + placebo; CTRL + DC: healthy + diacerein; OA + DC: osteoarthritis + diacerein. All parameters showed a non-normal distribution. Statistical significance p < 0.05: a vs. CTRL; b vs. OA; c vs. CTRL + DC; d vs. OA + DC