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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Bone Miner Res. 2014 Oct;29(10):2262–2275. doi: 10.1002/jbmr.2256

Figure 3. TH is essential for increased expression of Ihh, Osx, Col10 and OC in epiphyseal chondrocytes during SOC formation.

Figure 3

Five consecutive sections were probed by immunohistochemistry for type 2 collagen (Col2), type 10 collagen (Col10), Ihh, osteocalcin (OC) and Osx in the epiphyses of vehicle treated Tshr+/−, Tshr−/− and TH treated Tshr−/− mice at day 7, 10 and 14. Chondrogenic cells (CC), the secondary ossification center (SOC) and bone in the epiphyses of the tibias are labeled. Arrows in red indicate OC-positive and Osx-positive cells.