Table 3.
Common genetic variations in IGF-1, IGFBP-3 and IGFR and concentrations of IGF-I, IGFBP-3 and their ratio, and mammographic density
| IGF-Ia (nmol/l) | IGFBP-3a (nmol/l) | Ratioa | %densityb | Absolute dense areab | Non-dense areab | |||
|---|---|---|---|---|---|---|---|---|
| IGF-1 | ||||||||
| rs1549593 | Minor frequency allele Major frequency allele |
A1/A1 A1/A2 A2/A1 |
||||||
|
| ||||||||
| 0.GG | G = 0.80 T = 0.20 |
333 | 15.91 (15.35–16.48) | 116.7 (114.4–119.0) | 0.13 (0.13–0.14) | 36.60 (34.87–38.33) | 48.67 (45.196–52.15) | 83.29 (79.99–86.59) |
| 1.GT | 169 | 14.35 (13.74–15.32) | 113.5 (110.3–116.8) | 0.12 (0.12–0.13) | 35.68 (33.25–38.10) | 46.07 (41.18–50.96) | 82.27 (77.64–86.91) | |
| 2.TT | 18 | 15.17 (12.78–17.56) | 112.4 (102.6–122.3) | 0.13 (0.12–0.15) | 40.76 (33.31–48.20) | 59.16 (44.19–74.14) | 80.15 (65.95–94.35) | |
| ptrend# | 0.01 | 0.09 | 0.02 | 0.90 | 0.93 | 0.62 | ||
|
| ||||||||
| rs1520220 | Frequency allele 1 Frequency allele 2 |
A1/A1 A1/A2 A2/A1 |
||||||
|
| ||||||||
| 0.CC | C = 0.76 G = 0.24 |
287 | 15.06 (14.44–15.68) | 114.7 (112.2–117.3) | 0.13 (0.13–0.13) | 36.31 (34.43–38.19) | 47.27 (43.50–51.04) | 82.76 (79.18–86.33) |
| 1.CG | 179 | 15.55 (14.78–16.32) | 115.5 (112.3–118.6) | 0.13 (0.13–0.1) | 36.46 (34.10–38.81) | 50.30 (45.59–55.02) | 81.96 (77.48–86.43) | |
| 2.GG | 37 | 16.50 (14.80–18.20) | 122.5 (115.6–129.5) | 0.13 (0.12–0.15) | 34.70 (29.47–39.93) | 40.22 (29.73–50.71) | 81.67 (71.72–91.62) | |
| ptrend# | 0.10 | 0.10 | 0.28 | 0.74 | 0.81 | 0.76 | ||
|
| ||||||||
| rs6220 | Frequency allele 1 Frequency allele 2 |
A1/A1 A1/A2 A2/A1 |
||||||
|
| ||||||||
| 0.AA | A = 0.71 G = 0.29 |
253 | 15.11 (14.46–15.76) | 115.5 (112.8–118.1) | 0.13 (0.13–0.13) | 36.23 (34.25–38.22) | 47.12 (43.12–51.12) | 83.02 (79.23–86.81) |
| 1.AG | 197 | 15.37 (14.63–16.11) | 114.4 (111.4–117.4) | 0.13 (0.13–0.14) | 36.59 (34.34–38.83) | 50.05 (45.53–54.56) | 80.88 (76.60–85.16) | |
| 2.GG | 50 | 16.16 (14.69–17.62) | 121.1 (115.2–127.1) | 0.13 (0.12–0.14) | 35.77 (31.28–40.26) | 42.74 (33.70–51.78) | 84.37 (75.80–92.94) | |
| ptrend# | 0.22 | 0.33 | 0.39 | 0.99 | 0.55 | 0.86 | ||
| IGFBP–3 | ||||||||
|
| ||||||||
| rs2854744 | Frequency allele 1 Frequency allele 2 |
A1/A1 A1/A2 A2/A1 |
||||||
|
| ||||||||
| 0.GG | G = 0.72 T = 0.28 |
280 | 15.04 (14.42–15.66) | 109.6 (107.3–112.0) | 0.14 (0.13–0.14) | 37.08 (35.20–38.97) | 48.88 (45.13–52.62) | 80.91 (77.33–84.49) |
| 1.GT | 214 | 15.65 (14.94–16.36) | 120.9 (118.2–123.6) | 0.13 (0.12–0.13) | 35.49 (33.32–37.65) | 47.57 (43.26–51.88) | 84.47 (80.35–88.58) | |
| 2.TT | 43 | 16.84 (15.29–18.40) | 131.4 (125.4–137.4) | 0.13 (0.12–0.14) | 36.16 (31.31–41.01) | 46.28 (36.65–55.91) | 83.82 (74.62–93.02) | |
| ptrend# | 0.03 | <.0001 | 0.02 | 0.38 | 0.55 | 0.26 | ||
| IGFR | ||||||||
|
| ||||||||
| rs2229765 | Frequency allele 1 Frequency allele 2 |
A1/A1 A1/A2 A2/A1 |
||||||
|
| ||||||||
| 0.GG | G = 0.67 A = 0.33 |
231 | 15.54 (14.86–16.23) | 116.0 (113.1–118.8) | 0.13 (0.13–0.14) | 35.83 (33.74–37.91) | 47.16 (43.01–51.31) | 82.28 (78.32–86.24) |
| 1.GA | 238 | 14.87 (14.19–15.55) | 114.6 (111.9–117.4) | 0.13 (0.12–0.13) | 36.66 (34.60–38.71) | 47.73 (43.64–51.83) | 82.36 (78.45–86.27) | |
| 2.AA | 53 | 16.48 (15.07–17.88) | 120.7 (115.0–126.5) | 0.13 (0.12–0.14) | 34.20 (29.82–38.58) | 45.17 (36.44–53.90) | 82.39 (74.06–90.72) | |
| ptrend# | 0.86 | 0.47 | 0.73 | 0.85 | 0.85 | 0.60 | ||
a
Means and (95% confidence intervals), adjusted by age, state, batch of laboratory analyses and BMI
b
Means and (95% confidence intervals), adjusted by age, state and BMI
#
p-value for a linear trend in hormone/density levels across genotype categories estimated by assigning scores equal to the number of minor alleles to the categories (0, 1 or 2 alleles).