Table 2.
Association of race and risk of conventional adenomas and serrated polyps in people ≤ 50 and > 50 years of age
| ≤ 50 years | > 50 years | |||||||
|---|---|---|---|---|---|---|---|---|
| Conventional Adenoma | Black (n=21) | White (n=390) | RRa (95% CI) | Black (n=172) | White (n=2022) | RRa (95% CI) | ||
| Any | 10 | 130 | 1.0 | 1.70c (0.99–2.92) | 82 | 958 | 1.0 | 1.08 (0.92–1.27) |
| Advanced Histologyb | 4 | 19 | 1.0 | 5.52c (1.87–14.97) | 22 | 228 | 1.0 | 1.25 (0.86–1.90) |
| Any Advancedb | 4 | 26 | 1.0 | 4.05c (1.43–11.46) | 23 | 288 | 1.0 | 1.05 (0.71–1.56) |
| Proximal | 7 | 90 | 1.0 | 1.72 (0.85–3.49) | 63 | 649 | 1.0 | 1.24d (1.00–1.53) |
| Distal | 6 | 56 | 1.0 | 1.93 (0.89–4.24) | 49 | 583 | 1.0 | 1.08 (0.84–1.38) |
| Serrated Polyp | ||||||||
| Any | 5 | 118 | 1.0 | 0.75 (0.34–1.62) | 35 | 623 | 1.0 | 0.65d (0.49–0.87) |
| Proximal | 2 | 29 | 1.0 | 1.17 (0.28–4.89) | 13 | 206 | 1.0 | 0.67 (0.40–1.16) |
| Distal | 4 | 101 | 1.0 | 0.69 (0.28–1.69) | 27 | 518 | 1.0 | 0.61d (0.43–0.86) |
RR for black race compared to white race adjusted for age, sex, study treatment assignment, and follow-up time
Advanced histology adenoma includes lesions with 25% or more villous histology; any advanced adenoma includes adenomas that have advanced histology, large size, high-grade dysplasia, and/or invasive cancer.
p-value for differences between younger blacks and whites for any conventional adenoma (p=0.06), advanced histology (p =0.002), and any advanced adenoma (p =0.008).
p-value for difference between older blacks and whites for any proximal conventional adenoma (p=0.05), serrated polyp (p=0.004) and distal serrated polyps (p =0.004).