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. Author manuscript; available in PMC: 2016 Jun 18.
Published in final edited form as: Chem Biol. 2015 Jun 18;22(6):776–784. doi: 10.1016/j.chembiol.2015.05.008

Figure 1.

Figure 1

Probing juxtamembrane segment (JM) structure within full length EGFR on the cell surface using bipartite tetracysteine display (Luedtke et al., 2007; Scheck and Schepartz, 2011) and TIRF microscopy.

(A) EGF and TGF-α induce different structures within the EGFR JM (Luedtke et al., 2007; Scheck et al., 2012; Scheck and Schepartz, 2011).

(B) Helical wheel diagrams of five EGFR variants used previously to distinguish anti-parallel coiled coil arrangements. For sequences, see Figure S1A. In CCH-6, the Cys-Cys motifs are separated axially by a helical turn and do not assemble a ReAsH binding site (see also Figure S1).