Table II.
Univariate and multivariate survival analysis (Cox regression model) for overall survival of the PDAC patients (n=80).
| Variables | HR (95% CI) | P-value |
|---|---|---|
| Univariate | ||
| Gender (male vs. female) | 0.749 (0.339–1.652) | 0.474 |
| Age (years) (>60 vs. ≤60) | 1.846 (0.694–4.908) | 0.219 |
| Tumor size (cm) (>2 vs. ≤2) | 1.092 (0.500–2.386) | 0.824 |
| Tumor differentiation (poor vs. well + moderate) | 3.233 (1.654–4.265) | 0.013a |
| Tumor stage (III+IV vs. I+II) | 2.989 (1.678–3.476) | 0.015a |
| Tumor margin (positive vs. negative) | 0.411 (0.160–1.056) | 0.065 |
| Lymph node metastasis (present vs. absent) | 1.603 (1.123–2.551) | 0.034a |
| Neural invasion (positive vs. negative) | 2.113 (0.888–5.030) | 0.091 |
| Tumor recurrence (local and regional metastasis vs. none) | 1.875 (1.123–3.522) | 0.026a |
| miR-153 expression (low vs. high) | 2.652 (1.459–3.188) | 0.008a |
| Multivariate | ||
| Tumor size (cm) (>2 vs. ≤2) | 1.670 (0.787–3.545) | 0.182 |
| Tumor differentiation (poor vs. well + moderate) | 1.031 (0.492–2.162) | 0.936 |
| Tumor stage (III+IV vs. I+II) | 2.034 (1.398–2.573) | 0.005a |
| Tumor margin (positive vs. negative) | 1.971 (0.827–4.696) | 0.126 |
| Lymph node metastasis (present vs. absent) | 2.119 (1.505–2.499) | 0.017a |
| Neural invasion (positive vs. negative) | 1.892 (0.940–3.808) | 0.074 |
| Tumor recurrence (local and regional metastasis vs. none) | 3.225 (2.408–4.234) | 0.007a |
| miR-153 expression (low vs. high) | 4.123 (2.456–5.033) | 0.038a |
HR, hazard ratio; CI, confidence interval.
a
Statistically significant. PDAC, pancreatic ductal adenocarcinoma.