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Cell migration in the droplet test (A) and the influence of several inhibitors of cell signaling pathways on the OVCAR-3 cells following treatment with the control (B1), aPC (B2), PD98059 an ERK inhibitor (B3), UO126 an MEK-1/2 kinase inhibitor (B4), GGTI-298 an inhibitor of Rho GTPases (B5), FTI-277 an inhibitor of farnesyl transferase (B6) on aPC-induced cell migration from the droplet were analyzed and quantified (C). aPC, active protein C.
