TABLE 2.
Univariate and Multivariate Cox proportional hazard models with time to MCI/dementia conversion as dependent variable (n = 130)
| Did not Convert to MCI or Dementia during follow-up N=104 | Converted to MCI or Dementia during follow-up N=26 | Univariate test for time to conversion Hazard Ratio (HR) [95% CI] (chi-square, p-value) | Multivariate test for time to conversion Hazard Ratio [95% CI] (chi-square, p-value) | |
|---|---|---|---|---|
| Age (yrs) | 73.04 (5.95) | 75.31 (6.73) | 1.05 [0.99–1.11] (χ(1)2=2.85, p=.09) | - |
| %Male | 20.19 (n=21) | 34.62 (n=9) | 0.55 [0.24–1.23] (χ(1)2=2.11, p=.15) | |
| %White | 90.38 (n=94) | 88.46 (n=23) | 0.66 [0.20–2.19] (χ(1)2=0.47, p=.49) | |
| %Currently Married | 45.63 (n=47) | 44.00 (n=11) | 1.01 [0.46–2.23] (χ(1)2=0.001, p=.98) | |
| Education (yrs) | 13.42 (2.44) | 14.27 (2.71) | 1.09 [0.94–1.26] (χ(1)2=1.31, p=.25) | - |
| Cumulative Illness Rating Scale - Geriatric | 10.33 (3.37) N=103 | 11.81 (2.32) | 1.13 [1.01–1.26] (χ(1)2=4.91, p=.03) | 1.13 [1.01–1.27] (χ(1)2=4.23, p=.04) |
| Median Income | $45,481 ($20,060) | $48,000 ($19,444) | 1.09 [0.89–1.32] (hazard per $10,000) (χ(1)2=0.67, p=.41) | - |
| Interpersonal Support Evaluation List (ISEL - Total) | ||||
| Total | 37.73 (6.86) | 36.31 (7.85) | 0.96 [0.92–1.02] (χ(1)2=1.96, p=.16) | |
| Self-esteem | 8.26 (2.26) | 7.65 (2.94) | 0.90 [0.77–1.06] (χ(1)2=1.91, p=.17) | |
| Belonging | 9.89 (2.26) | 9.12 (2.23) | 0.86 [0.74–0.99] (χ(1)2=4.05, p=.04) | 0.88 [0.74–1.03 (χ(1)2=2.46, p=.12) |
| Appraisal | 9.91 (2.28) | 9.88 (2.23) | 0.96 [0.82–1.12] (χ(1)2=0.24,=0.62) | |
| Tangible | 9.66 (2.44) | 9.65 (2.53) | 0.97 [0.82–1.15] (χ(1)2=0.12, p=.73) | |
| Hamilton Depression Rating Scale-17 | 18.85 (3.39) | 18.08 (3.08) | 0.98 [0.87–1.11] (χ(1)2=0.10, p=.76) | - |
| Duration of Past Depression (mos) | 189.83 (499.84) | 125.38 (243.59) | 0.99 [0.98–1.02] (hazard per year) (χ(1)2=0.02, p=.88) | - |
| Baseline global neuropsychological score | −0.41 (0.86) | −0.70 (0.64) | 0.56 [0.36–0.87] (χ(1)2=6.66, p=.001) | 0.69 [0.43–1.09] (χ(1)2=2.53, p=.11) |
| %Randomized to Donepezil Treatment | 55.77 (n=58) | 34.62 (n=9) | 0.60 [0.27–1.36] (χ(1)2=1.50, p=.22) | - |
HR = Hazard Ratio; MCI = Mild Cognitive Impairment; ISEL = Interpersonal Support Evaluation List