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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Investig Med. 2008 Feb;56(2):515–517. doi: 10.231/JIM.0b013e318165e89d

FIGURE 1.

FIGURE 1

Schematic representation of the structural organization of nuclear receptors. All nuclear receptors share a common structural organization with multiple distinct functional domains. The N-terminal A/B domain contains at least 1 constitutively active transactivation region (activation function 1) and several autonomous transactivation domains. The C domain, the most conserved region, is responsible for DNA-binding specificity and for both homodimerization and heterodimerization of receptors. The D domain is a less conserved flexible hinge region between DNA-binding and the C-terminal ligand–binding domain E. The D domain contains the nuclear localization signal and also serves as docking site for cofactors. The E domain is a moderately conserved domain with a ligand-dependent transactivation function called activation function 2. Some members also have C-terminal F domain, whose sequence is extremely variable. AF-1 indicates activation function 1; AF-2, activation function 2.