Table 1.
Results of the Analysis of Tumor Volume and Tumor Metabolism in LAPC4-CR Xenograft Models Using [18F]-FDG-PET/CT
| Mouse ID |
Tumor Growth |
Caliper Volume Estimate |
CT Tumor Volume |
FDG Metabolic Volume |
FDG Metabolism Max |
FDG Metabolism Mean70% |
TBR Mean70%/Liver |
TMR Mean70%/Muscle |
Intratumor Heterogeneity |
||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (d) | (mm3) | (mm3) | (mm3) | (ID/cm3⁎wt) | (ID/cm3⁎wt) | (ID/cm3⁎wt)/liver | (ID/cm3⁎wt)/muscle | Range (ID/cm3⁎wt) | IQR (ID/cm3⁎wt) | IQR (%) | |
| 03A00 | 35 | 133.1 | 206.0 | 19.4 | 4.39 | 3.50 | 10.3 | 19.5 | 4.2 | 1.9 | 121% |
| 03A01 | 35 | 111.6 | 160.2 | 30.9 | 1.84 | 1.49 | 4.7 | 4.0 | 1.5 | 0.5 | 42% |
| 03B00 | 43 | 156.8 | 228.2 | 5.0 | 2.73 | 2.18 | 7.5 | 4.4 | 1.9 | 0.6 | 50% |
| 03B01 | 43 | 185.7 | 247.1 | 12.8 | 1.93 | 1.51 | 3.6 | 3.6 | 1.3 | 0.5 | 58% |
| 03C00 | 43 | 116.6 | 167.7 | 6.2 | 2.95 | 2.38 | 6.6 | 10.8 | 2.6 | 1.0 | 119% |
| 03C01 | 43 | 113.1 | 222.7 | 23.4 | 1.82 | 1.42 | 5.1 | 5.5 | 1.4 | 0.5 | 52% |
| 03C03 | 43 | 152.6 | 122.0 | 4.3 | 1.75 | 1.37 | 4.6 | 8.1 | 1.3 | 0.5 | 83% |
| 04F01 | 49 | 158.1 | 81.3 | 6.8 | 3.68 | 2.97 | 8.5 | 7.2 | 3.2 | 1.7 | 179% |
| 04F03 | 49 | 210.7 | 253.2 | 37.5 | 2.37 | 1.90 | 6.3 | 3.0 | 2.0 | 0.8 | 59% |
| 04A00 | 84 | 93.8 | 100.8 | 2.3 | 1.59 | 1.29 | 4.2 | 5.0 | 1.4 | 0.4 | 65% |
| 04C00 | 84 | 161.4 | 278.7 | 27.1 | 3.82 | 2.99 | 10.7 | 9.0 | 3.3 | 1.0 | 51% |
| 04E03 | 84 | 168.8 | 148.2 | 11.0 | 2.16 | 1.73 | 6.7 | 3.3 | 1.4 | 0.7 | 72% |
| 04F00 | 98 | NA | 227.5 | 27.8 | 3.96 | 3.05 | 8.5 | 12.7 | 3.2 | 1.2 | 59% |
| Mean ± standard deviation | 146.9 ± 34.2 | 188.0 ± 62.4 | 16.5 ± 11.8 | 2.7 ± 1.0 | 2.1 ± 0.8 | 6.7 ± 2.3 | 7.4 ± 4.7 | 2.2 ± 1.0 | 0.9 ± 0.5 | 78% ± 39% | |
| Median | 154.7 | 206.0 | 12.8 | 2.4 | 1.9 | 6.6 | 5.5 | 1.9 | 0.7 | 59% | |
| 95% CI of median | [113.1, 168.8] | [122.0, 247.1] | [5.0, 27.8] | [1.8, 3.8] | [1.4, 3.0] | [4.6, 8.5] | [3.6, 10.8] | [1.4, 3.2] | [0.5, 1.2] | [51%, 119%] | |
The [18F]-FDG metabolism in tumors was measured as the maximum (max) and mean (mean70%) [18F]-FDG uptake within the anatomic tumor volume. Across the cohort, [18F]-FDG uptake was normalized by the injected activity and body weight of the individual mouse (ID/cm3*wt). Tumor metabolism was compared to background metabolism in healthy liver, expressed as the TBR (ID/cm3*wt)/liver, and compared to skeletal muscle in a contralateral limb, expressed as the TMR (ID/cm3*wt)/muscle. The intratumor heterogeneity was calculated by comparing local maxima [18F]-FDG metabolism of subregions within each tumor and was expressed as the differences between highest and lowest of the subregions (range) and between the quartiles (IQR).
NA indicates that caliper measurements were not recorded at the time of imaging.