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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Thromb Haemost. 2014 Dec 11;13(1):57–71. doi: 10.1111/jth.12770

Figure 2. Effect of PAR-4 deficiency on serotonin levels and liver injury in ANIT-treated mice.

Figure 2

Wild-type (WT) and PAR-4−/− mice were fed control diet (AIN-93M) or an identical diet containing 0.025% ANIT for 4 weeks. (A) Plasma serotonin, (B) serum bile acids, (C) serum ALT activity and (D) serum ALP activity were determined as described in Materials and Methods. (E) Necrotic lesion size, number and area were determined as described in Materials and Methods. (F) Representative photomicrographs showing hematoxylin and eosin–stained liver sections (200X). Arrow indicates area of biliary fibrosis and portal inflammation. Data are expressed as mean ± SEM; n = 5 mice per group for control diet and 10–11 mice per group for ANIT-treated mice. *p<0.05 vs. control diet within genotype and #p<0.05 vs. WT mice fed the same diet.