Table 1.
Demographics and Pharmacokinetics
| Mean ± SD | Range | ||
|---|---|---|---|
| Demographics | Age (years) | 40.8 ± 5.8 | 35 – 48 |
| Female (N=5, 100%) | --- | --- | |
| Years post-RYGB | 3.5 ± .31 | 3.2 – 4.0 | |
| Height (inches) | 64.2 ± 5.2 | 55 – 67 | |
| Weight (kg) | 89.6 ± 7.5 | 78.4 – 97.7 | |
| BMI (kg/m2) | 31.6 ± 2.1 | 28.7 – 33.7 | |
| Pre-surgery weight (kg) | 125.8 ± 11.1 | 110.5 ± 138.6 | |
|
| |||
| Pharmacokinetics | Dose of alcohol (gm) | 26.9 ± 2.3 | 23.5 – 29.3 |
| Cmax (mg/dl) | 138.4 ± 28.6 | 98.0 – 170.0 | |
| Tmax (min) | 5.4 ± 3.1 | 2 –10 | |
| AUC0–60min (mg/dl x min)* | 4574.1 ± 569.9 | 3965.8 – 5269.5 | |
|
| |||
| BAC mg/dL (minutes post-drink) | 1 | 43.4 ± 10.2 | 34.0 – 60.0 |
| 2 | 86.8 ± 34.5 | 44.0 –125.0 | |
| 3 | 114.2 ± 35.2 | 75.0 –153.0 | |
| 4 | 127.0 ± 36.2 | 83.0 –168.0 | |
| 5 | 126.0 ± 31.7 | 95.0 –170.0 | |
| 7.5 (N=2) | 143.0 ± 5.7 | 139.0 –147.0 | |
| 10 | 108.6 ± 12.4 | 93.0 –122.0 | |
| 20 | 80.2 ± 10.0 | 70.0–91.0 | |
| 60 | 48.6 ± 4.8 | 44.0 – 56.0 | |
*
0 time-point in AUC calculation confirmed by Breathalyzer assessment before the dose was administered. All other alcohol concentrations obtained from blood.