Table 2.
Effects of the MEMM on gastric lesions induced by ethanol in rats pretreated with L- NAME or NEM
| Pre-treatment | Treatment | Dose, mg/kg | Ulcer area (mm 2 ) |
|---|---|---|---|
| Saline | 10% DMSO | - | 33.33 ± 1.84 |
| CBX | 100 | 3.17 ± 0.31a | |
| MEMM | 500 | 0.83 ± 0.40a | |
| Quercitrin | 250 mg/kg | 1.62 ± 0.74a | |
| L-NAME | 10% DMSO | - | 49.38 ± 3.64b |
| CBX | 100 mg/kg | 7.00 ± 0.76ce | |
| MEMM | 500 mg/kg | 5.25 ± 0.98cf | |
| Quercitrin | 250 mg/kg | 22.48 ± 1.93cg | |
| NEM | 10% DMSO | - | 61.50 ± 4.62b |
| CBX | 100 mg/kg | 12.00 ± 2.46dh | |
| MEMM | 500 mg/kg | 54.33 ± 4.82di | |
| Quercitrin | 250 mg/kg | 38.85 ± 5.21dj |
Values are mean ± SEM (n = 6 rats/group).
One-way ANOVA followed by Student–Newman–Keuls.
a,bData differed significantly (p < 0.05) when compared to the (saline + 10% DMSO)- pretreated group.
cData differed significantly (p < 0.05) when compared to the (L-NAME + 10% DMSO)- pretreated group.
dData differed significantly (p < 0.05) when compared to the (NEM + 10% DMSO)- pretreated group.
e,hData differed significantly (p < 0.05) when compared to the (saline + CBX)-pretreated group.
f,iData differed significantly (p < 0.05) when compared to the (saline + MEMM)-pretreated group.
g,jData differed significantly (p < 0.05) when compared to the (saline + quercitrin)-pretreated group.