Appendix Table 2.

Costs of One-Time and Recurrent Treatments of Adverse Effects

Cost per 3-month cycle of one-time plus recurrent costs	Adverse Effects	Coding	Intervention	RVUs/medication amount		Payment ($)	Weighting*	Charges per 3-month cycle	Cost per cycle	Patient Days, Weighted	Comments
Urinary Incontinence	Chronic management of urinary incontinence		anticholinergic agent (tolteridine)	60 tablets (1mg)		140.20	100%	3	$ 420.59		60 tabs per month
	One-time costs	APC 0126	level I Urinary and Anal Procedures		1.0356	74.63	74%	l	$ 55.23	0.74	Includes CPT 51736 (urodynamics/uroflowmetry) & 53601 (dilate urethra stricture)
		APC 0164	level II Urinary and Anal Procedures		2.0077	144.69	25%	1	$ 36.17	0.50	Includes CPT 0084T (temporary prostate urethral stent) and CPT 53621 (dilate urethra stricture)
		APC 0150	level V Anal/Rectal Procedures		30.1606	2.173.55	1%	1	$ 21.74	0.10	Includes CPT 46762 (artificial sphincter)
		CPT 99214	Office/outpatient visit, estimated		1.91	82.31	100%	2	$ 164.62	l.00
									$ 698.35	2.34
Erectile Dysfunction (ED)	Chronic management of ED		sidenafil citrate 50mg tab/week	30 tablets (50mg)		408.34	97%	0.4	$ 63.37		Assuming 1 tablet/week
	One-time costs**	HCPCS	vacuum erection device			546.41	10%	1	$ 21.86
		CPT 54405	prosthesis (insert multi-comp penis pros)		144.1246	10.386.45	5%	1	$ 207.73	0.10
			Caverject pens, intracavernous injections	2 pens		65.57	5%	26	$ 34.09		Assuming 2.2 uses/week
		CPT 99214	Office/outpatient visit, estimated		1.91	82.31	100%	2	$ 65.85	1.00
									$ 392.90	1.10
Gastrointestinal Adverse Effects	Chronic management of GI bleeding		6 months anti-inflammatory enema: 3g/day sulfazine	91.2g per month		101.50	100%	6	$ 609.01	11.00
	One-time costs	APC 0143	colonoscopy for bleeding		8.8486	637.68	30%	1	$ 191.30	0.30
			sigmoidoscopy/ablation			637.68	30%	3	$ 573.91	0.45
			6 months anti-inflammatory enema for refractory cases	91.2g per month		101.50	30%	6	$ 182.70	3.00
									$ 1.556.92	14.75
Urinary Obstruction	Chronic management urinary obstruction		Tamsulosin	1 30-day supply		94.64	100%	3	$ 283.93
	One-time costs	CPT 99214	office/outpatient visit, estimated		1.91	82.31	100%	2	$ 164.62	1.00
		APC 0163	level IV Cystourethroscopy & other Genitourinary Procedures		36.0774	2.599.94	2%	1	$ 52.00	0.04
		CPT 52000	Cystoscopy		5.97	430.49	100%	1	$ 430.49	2.00
		APC 0126	level I Urinary and Anal Procedures		1.0356	74.63	50%	1	$ 37.31	1.00	Includes CPT 51736 (urodynamics/uroflowmetry) & 53601 (dilate urethra stricture)
									$ 968.36	4.04
Recurrent costs only
Urinary Incontinence	Chronic management of incontinence		anticholinergic agent (tolteridine)	60 tabs (1mg)		140.20	100%	3	$ 420.59
		CPT 99214	Office/outpatient visit, estimated		1.91	82.31	100%	1	$ 82.31	0.50
									$ 502.90	0.50
Erectile Dysfunction	Chronic management of ED		sidenafil citrate 50mg tab/week	30 tabs (50mg)		408.34	97%	0.4	$ 63.37		Assuming 1 tablet/week
			Caverject pens, intracavernous injections	2 pens		65.57	5%	6	$ 7.87		Assuming 1 use every 2 weeks
		CPT 99214	Office/outpatient visit, estimated		1.91	82.31	100%	1	$ 82.31	0.50
									$ 153.55	0.50
Gastrointestinal Adverse Effects	Chronic management of GI bleeding		6 months anti-inflammatory enema: 3g/day sulfazine	91.2g per month		101.50	10%	1.5	$ 15.23	0.55
		APC 0143	colonoscopy for bleeding		8.8486	637.68	5%	0.025	$ 0.80	0.00125
			s igmoidoscopies/ablation			637.68	5%	0.075	$ 2.39	0.0005625
			6 months anti-inflammatory enema for refractory cases	91.2g per month		101.50	5%	1.5	$ 7.61	0.3
									$ 26.03	0.85
Urinary Obstruction	Chronic urinary obstruction		Tamsulosin	1 30-day supply		94.64	100%	3	$ 283.93
		CPT 99214	Office/outpatient visit, estimated		1.91	82.31	100%	1	$ 82.31	0.50
									$ 366.25	0.50

ABBR: RVU: Relative value units: CPT: Current procedural terminology: APC: Ambulatory Payment Codes; HCPCS: Health Care Common Procedure Coding System

^*Weighting: Weighted averages of costs represent typical case mixes (severity, treatment modality) derived from structured interviews with clinicians

^**For the purposes of this model it is assumed that 40% of men with erectile dysfunction seek treatment