Fig. 2.

Comparative gene map of the human 22q11.2 region homologues. Protein Basic Local Alignment Search Tool (blastp) analysis on UniProtKB using the reciprocal best hits method was used to compare protein sequences to identify homologues of the 46 human protein-coding genes in the mouse (M. musculus), 40 conserved genes; zebrafish (D. rerio), 37 conserved genes; fruit fly (D. melanogaster), 22 conserved genes and worm (C. elegans), 17 conserved genes. Locations of human genes and putative homologues were mapped using NCBI Gene. Horizontal bars indicate clusters of two or more genes; fine lines otherwise join homologues between species. See text for details