Table 1.
Effects of Aristolochia ringens (AR) extracts against sarcoma-180 (ascites) in BALB/c mice.
| Treatments | Dose (mg/kg) | Body weight (g) |
Day 12 |
Tumor growth inhibition (%) | Mortality (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 5 | Day 9 | Body weight (g) | Weight of tumor (g) | Volume of ascitic fluid (mL) | Number of tumor cells (× 107) | ||||
| Normal saline | (0.2 mL/mouse) | 22.91 ± 0.74 | 24.82 ± 0.86 | 28.64 ± 1.19 | 29.36 ± 1.44 | 9.73 ± 1.00 | 9.88 ± 0.96 | 277.86 ± 37.20 | 0 | 0 |
| 5-FU | 20 | 21.14 ± 0.55* | 20.86 ± 0.63*** | 17.71 ± 0.84*** | 16.60 ± 0.75*** | 0.50 ± 0.21*** | 0.52 ± 0.22*** | 6.00 ± 2.45*** | 97.84 | 0 |
| AR-A001 | 100 | 20.43 ± 0.48** | 20.86 ± 0.55*** | 21.43 ± 0.95***,## | 21.43 ± 1.00***,## | 5.86 ± 1.37*,## | 6.01 ± 1.35*,## | 73.47 ± 15.71***,## | 73.56 | 0 |
| AR-A002 | 100 | 20.57 ± 0.37** | 18.43 ± 0.20***,# | 16.83 ± 0.48*** | 16.67 ± 1.33*** | 1.85 ± 0.98*** | 2.00 ± 1.04*** | 53.75 ± 27.17*** | 80.66 | 57.14 |
| AR-A003 | 100 | 20.71 ± 0.42* | 17.71 ± 0.42***,### | 16.50 ± 0.22*** | 15.00 ± 3.00* | 2.71 ± 2.71 | 2.75 ± 2.75 | 63.25 ± 63.25 | 77.24 | 71.43 |
| AR-A004 | 80 | 21.00 ± 0.62* | 20.14 ± 0.55c | 18.57 ± 0.65*** | 17.29 ± 1.32*** | 2.56 ± 0.71***,# | 2.73 ± 0.74***,# | 77.34 ± 26.44***,# | 72.16 | 0 |
Data are presented as mean ± standard error of the mean (n = 7, n = 11 for control).
*p < 0.05, **p < 0.01, ***p < 0.001 versus normal saline.
#p < 0.05, ##p < 0.01, ###p < 0.001 versus 5-FU (one-way analysis of variance followed by Dunnett's multiple comparison test).
5-FU = 5-fluorouracil.