Table 2.
Effects of AR-A001 (80 mg/kg, 120 mg/kg) and AR-A004 extracts (100 mg/kg, 120 mg/kg) against sarcoma-180 (ascites) in BALB/c mice.
| Treatments | Dose (mg/kg) | Body weight (g) |
Day 12 |
Tumor growth inhibition (%) | Mortality (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Body weight (g) | Weight of tumor (g) | Volume of ascitic fluid (mL) | Number of tumor cells (× 107) | |||||||
| Day 1 | Day 5 | Day 9 | ||||||||
| Normal saline | (0.2 mL/mouse) | 21.40 ± 0.75 | 23.80 ± 0.86 | 27.20 ± 1.24 | 27.60 ± 1.12 | 9.81 ± 1.01 | 9.96 ± 0.77 | 474.25 ± 45.26 | 0 | 0 |
| 5-FU | 20 | 21.20 ± 0.58 | 22.60 ± 0.75 | 21.40 ± 1.08** | 20.60 ± 1.44** | 0.50 ± 0.22*** | 0.48 ± 0.22*** | 10.00 ± 4.18*** | 97.89 | 0 |
| AR-A001 | 80 | 20.80 ± 0.66 | 21.80 ± 1.07 | 22.60 ± 1.69* | 23.00 ± 1.70* | 4.91 ± 1.06**,## | 5.10 ± 1.07**,## | 138.55 ± 30.42***,## | 70.79 | 0 |
| 120 | 20.80 ± 0.66 | 21.20 ± 0.80* | 21.20 ± 1.07** | 20.80 ± 1.93* | 3.71 ± 1.08**,# | 3.70 ± 1.12**,# | 97.18 ± 31.07***,# | 79.51 | 0 | |
| AR-A004 | 100 | 20.80 ± 0.66 | 20.20 ± 1.07* | 18.60 ± 1.03***,# | 18.60 ± 1.12*** | 2.35 ± 0.92*** | 2.52 ± 0.99*** | 55.14 ± 22.88*** | 88.37 | 0 |
| 120 | 20.80 ± 0.66 | 20.80 ± 0.97* | 19.60 ± 1.50** | 22.50 ± 2.50 | 2.36 ± 2.36 | 2.50 ± 2.50 | 47.50 ± 47.50** | 89.98 | 60 | |
Data are presented as mean ± standard error of the mean (n = 5).
*p < 0.05, **p < 0.01, ***p < 0.001 versus normal saline.
#p < 0.05, ##p < 0.01 versus 5-FU (one-way analysis of variance followed by Dunnett’s multiple comparison test).
5-FU = 5-fluorouracil.