Table 3.
Effects of AR-A001 and AR-A004 extract against sarcoma-180 (solid) tumor in BALB/c mice.
| Treatments | Dose (mg/kg) | Body weight (g) |
Day 9 |
Day 13 |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 5 | Day 9 | Day 13 | Tumor volume (mm3) | Inhibition (%) | Tumor volume (mm3) | Inhibition (%) | ||
| Normal saline | (0.2 mL/mouse) | 21.80 ± 0.58 | 23.00 ± 0.55 | 23.80 ± 0.58 | 24.00 ± 0.32 | 1848.50 ± 108.31 | 0.00 | 2283.50 ± 136.58 | 0.00 |
| 5-FU | 20 | 21.80 ± 0.58 | 20.60 ± 1.17 | 18.80 ± 2.08* | 19.80 ± 2.15 | 676.80 ± 188.15*** | 63.39 | 1137.60 ± 247.45** | 50.18 |
| AR-A001 | 120 | 20.80 ± 0.86 | 21.20 ± 1.02 | 20.60 ± 1.21* | 20.80 ± 1.02* | 1260.40 ± 237.90*,# | 31.81 | 1611.00 ± 290.72* | 29.45 |
| AR-A004 | 110 | 20.80 ± 0.86 | 20.20 ± 1.50 | 19.80 ± 1.39* | 19.60 ± 1.21** | 818.10 ± 124.32*** | 55.74 | 1130.40 ± 137.88*** | 50.50 |
Values are mean ± standard error of the mean (n = 5).
*p < 0.05, **p < 0.01, ***p < 0.001 versus normal saline.
#p < 0.05 versus 5-FU (one-way analysis of variance followed by Dunnett’s multiple comparison test).
5-FU = 5-fluorouracil.