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. 2015 Jul 2;13:208. doi: 10.1186/s12967-015-0575-0

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© Gomez-Brouchet et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of regional anaesthesia on opioid induced hyperalgesia in diabetic mice. The actions of levobupivacaine sciatic nerve block on perioperative sufentanil induced hyperalgesia were evaluated by three behavioural tests: a von frey; b hot plate; c guarding pain behaviour. Diabetic control group 4 (C): no sufentanil, no levobupivacaine sciatic block, plantar incision; diabetic OIH group 5 (S): sufentanil, no levobupivacaine sciatic block, plantar incision; diabetic OIH + RA group 6 (S + RA): sufentanil, levobupivacaine sciatic block, plantar incision. *P < 0.05 compared group 5 to group 4 (control); ⁺ P<0.05 compared group 6 to group 4. AN after naloxone, BN before naloxone, B basal, C control, D day, H hour, g gram, PI plantar incision, RA regional anaesthesia, S sufentanil, s second. Data presented as mean ± SD.