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. 2015 Jul 2;13:208. doi: 10.1186/s12967-015-0575-0

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© Gomez-Brouchet et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histology of mouse hindpaws. The effect of levobupivacaine and sufentanil were tested on histopathology of diabetic and non-diabetic mouse hind paws at different days postsurgery: a non-diabetic mice 1 day (D1) after skin incision showing acute inflammatory infiltration with polynuclear cells and oedema. b Non-diabetic mice 7 days (D7) after skin incision showing myofibroblastic proliferation with some lymphocyte inflammatory cells. c Non-diabetic mice 14 days (D14) after skin incision showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation. d Non-diabetic mice with RA at D14 showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation. e Diabetic mice at D1 showing acute inflammatory infiltration with polynuclear cells and oedema. f Diabetic mice at D7 showing persistent acute inflammatory cells and oedema. g Diabetic mice at D14 showing persistent acute inflammatory cells and oedema. h Diabetic mice with regional anaesthesia at D14 showing wound healing of the conjunctive tissue with only few inflammatory cells and still fibroblastic superficial proliferation.