Fig. 8.

TNF regulates synthesis of IL-1β and IL-12p70. TNF^f/f (black), NsTNF^−/− (grey) and TNF^−/− (clear) mice were infected with M. tuberculosis H37Rv infection at a dose of 1 × 10³–1 × 10⁴ CFUs/brain by intracerebral inoculation. a TNF, b IL-1β and c IL-12p70 cerebral concentrations were measured by ELISA at 3 weeks post-infection. Data (mean ± SEM of the CFUs of 5–6 mice per time point) are representative of repeat experiments. *p ≤ 0.05