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. 2015 Jul 1;16(1):490. doi: 10.1186/s12864-015-1706-y

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© Wang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Pluripotent genes targeted by over-expressed miRNAs in stem cells. a. Venn diagram of pluripotent genes targeted by both up-and down-regulated miRNAs. b, activated modules commonly targeted by both up- and down-regulated miRNAs. The enlarged nodes represent the highly connected targets that are targeted by both up- and down-regulated miRNAs in stem cells, and they work for pluripotent signal pathways. c, down-regulated modules targeted by over-expressed miRNAs in stem cells. d, activated modules targeted by the miR-302-367 cluster in stem cells. e, an activated network targeted by miR-294