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. 2015 Jul 1;16(1):490. doi: 10.1186/s12864-015-1706-y

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© Wang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — DNA methylation mediates miRNA activations in stem cells. a, The methylation levels upstream and downstream from the miRNA start site. Down-regulated miRNAs have significantly higher methylation in upstream region when compared with up-regulated miRNAs. b, Detailed methylation profiling for regions that are 2000 bp upstream from the activated miRNAs. The top 30 down-regulated miRNAs (Additional file 1: Table S2) have higher methylation around -1000 bp (green highlighted in middle panel) than that of the top 30 up-regulated miRNAs (Additional file 1: Table S2, upper panel). The methylation profiling of a single down-regulated miRNA-133 as a representative example (bottom panel). c. Negative correlation between DNA methylation and miRNA expression. Red line represents regression line