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. 2015 Jul 1;16(1):490. doi: 10.1186/s12864-015-1706-y

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© Wang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — A system view of miRNAs primary mechanistic roles in maintaining pluripotency in pluripotent stem cells. MiRNAs directly repress both the DNA methylation system and the development, while indirectly regulate pluripotency genes. Reduced DNA methylation activates the miRNAs and pluripotent core factors for pluripotency. The activated circuit between miRNAs and DNA methylation, as well as the development inhibition, help stem cells to maintain the pluripotent state, see text for detail. The solid lines are directly derived from the present study and they represent direct interactions and the dash dark line represents indirect interactions, while dash green lines denote evidences from reference papers.