Table 2.
Hemodynamic characteristics of renal responders and non-responders at baseline
| Variables | All | 0.1 ml/kg/hour | 0.2 ml/kg/hour | 0.3 ml/kg/hour | |||
|---|---|---|---|---|---|---|---|
| R | NR | R | NR | R | NR | ||
| N | 49 | 32 | 16 | 27 | 21 | 25 | 23 |
| Heart rate (bpm) | 98 ± 23 | 98 ± 22 | 97 ± 27 | 101 ± 22 | 94 ± 25 | 101 ± 22 | 94 ± 24 |
| Systolic arterial pressure (mmHg) | 109 ± 21 | 113 ± 24 | 102 ± 13 | 116 ± 25* | 101 ± 12 | 117 ± 25* | 101 ± 12 |
| Diastolic arterial pressure (mmHg) | 58 ± 13 | 60 ± 15 | 53 ± 8 | 63 ± 15* | 52 ± 8 | 64 ± 15* | 52 ± 8 |
| Mean arterial pressure (mmHg) | 75 ± 16 | 79 ± 17 | 70 ± 9 | 80 ± 17* | 68 ± 8.9 | 82 ± 17* | 68 ± 8.9 |
| Pulse pressure (mmHg) | 48 ± 19 | 50 ± 20 | 46 ± 17 | 51 ± 22 | 47 ± 15 | 50 ± 22 | 47 ± 15 |
| Resistivity index | 0.73 ± 0.09 | 0.71 ± 0.09* | 0.77 ± 0.06 | 0.70 ± 0.09* | 0.77 ± 0.63 | 0.70 ± 0.09* | 0.76 ± 0.06 |
| Systolic velocity (cm/s) | 42.8 ± 17.7 | 42.2 ± 16.4 | 45.6 ± 19.9 | 41.7 ± 14.3 | 45.3 ± 21.2 | 43.3 ± 13.5 | 43.3 ± 21.4 |
| Diastolic velocity (cm/s) | 11.4 ± 5.9 | 12.2 ± 6.4 | 10.2 ± 4.7 | 12.7 ± 6.5 | 10 ± 4.6 | 13.2 ± 6.6 | 9.7 ± 4.5 |
| Mean velocity (cm/s) | 21.8 ± 9.1 | 27.2 ± 10.7 | 27.9 ± 11.8 | 27.2 ± 9.9 | 27.7 ± 12.6 | 28.2 ± 9.5 | 26.5 ± 12.6 |
| Urine output (ml/kg/hour) | 0.69 ± 1.04 | 0.73 ± 0.85 | 0.65 ± 1.39 | 0.79 ± 0.88 | 0.61 ± 1.24 | 0.83 ± 0.9 | 0.57 ± 1.19 |
| Lactate, mean value (mmol/l) | 2.8 ± 2.6 | 2.7 ± 2.5 | 3.1 ± 3.1 | 2.8 ± 2.6 | 2.8 ± 2.8 | 2.9 ± 2.7 | 2.8 ± 2.6 |
| Number, n (%) | 41 (83.7) | 28 (87.5) | 12 (75) | 23 (85.2) | 17 (80.1) | 21 (84) | 19 (82.6) |
| ScvO2, mean value (%) | 65.6 ± 9.2 | 66 ± 7.5 | 64.7 ± 12.4 | 65.6 ± 7.8 | 65.5 ± 11.5 | 65.3 ± 8.3 | 65.8 ± 10.7 |
| Number, n (%) | 16 (32.7) | 10 (31.3) | 6 (37.5) | 9 (33.3) | 7 (33.3) | 8 (32) | 8 (34.8) |
| Norepinephrine rate (μg/kg/minute) | 0.31 ± 0.35 | 0.19 ± 0.14 | 0.23 ± 0.4 | 0.22 ± 0.21 | 0.33 ± 0.39 | 0.22 ± 0.20 | 0.33 ± 0.39 |
| Number, n (%) | 17 (35) | 7 (15) | 9 (19) | 3 (6) | 13 (27) | 3 (6) | 13 (27) |
| Fluids crystalloids, n (%) | 41 (85) | 29 (91) | 13 (81) | 25 (93) | 17 (81) | 23 (92) | 19 (83) |
| Colloids, n (%) | 14 (29) | 8 (25) | 3 (19) | 6 (22) | 5 (24) | 5 (20) | 6 (26) |
| Mixed, n (%) | 6 (13) | 5 (16) | 0 (0) | 4 (15) | 1 (5) | 3 (12) | 2 (9) |
| Volume (ml) | 1,224 ± 717 | 1,273 ± 555 | 1,125 ± 979 | 1,361 ± 534 | 1,048 8 ± 83 | 1,390 ± 545 | 1,044 ± 842 |
One patient received norepinephrine, had urinary retention and was not defined as a responder or non-responder. Baseline mixed venous saturation measured in two patients was 49 and 59 %, respectively. Results are shown as mean ± standard deviation or frequency (percentage). *Statistically significant difference versus non-responders for that threshold. n number of patients or measurements, NR non-responders, ScvO 2 central venous oxygen saturation, R responders