Fig. 5.

The response of male and female WT (solid bars) and oim/oim (hatched bars) cortical bone to treatment with ALN, ALN + RANK-Fc, RANK-Fc, or saline + RANK-Fc is compared with the same genotype and same sex treated with Saline based on a Kruskal-Wallis test with Bonferroni correction (*p < 0.05). Parameters illustrated in individual graphs are: mineral-to-matrix ratio (M/M), carbonate-to-mineral ratio (C/P) × 10³, crystal size and perfection (XST), collagen maturity (CM), and acid phosphate substitution (HPO4).