Table 1.
FTIR imaging heterogeneities (FWHM*) for cortical bone
| Tissue source | M/M | p value | C/P | XST | CM | HPO4 |
|---|---|---|---|---|---|---|
| Saline WT | ||||||
| Male | 3.02 ± 0.30 | 0.0028 ± 0.00037 | 0.157 ± 0.041 | 0.83 ± 0.28 | 0.083 ± 0.031 | |
| Female | 2.31 ± 0.67 | 0.0026 ± 0.00060 | 0.114 ± 0.016 | 0.46 ± 0.11 | 0.067 ± 0.014 | |
| Saline oim/oim | ||||||
| Male | 2.47 ± 0.59 | 0.0020 ± 2.4E-05 | 0.156 ± 0.027 | 0.61 ± 0.048 | 0.070 ± 0.0064 | |
| Female | 1.80 ± 0.32 | 0.0029 ± 0.00035 | 0.148 ± 0.039 | 0.54 ± 0.14 | 0.095 ± 0.042 | |
| Rank-Fc WT | ||||||
| Male | 2.58 ± 0.28 | 0.0028 ± 0.00041 | 0.176 ± 0.010 | 0.55 ± 0.17 | 0.066 ± 0.016 | |
| Female | 2.46 ± 0.12 | 0.0020 ± 0.00062 | 0.123 ± 0.040 | 0.53 ± 0.22 | 0.87 ± 0.05 | |
| Rank-FC oim/oim | ||||||
| Male | 3.60 ± 0.79 | 0.043 | 0.0025 ± 0.00031 | 0.137 ± 0.017 | 0.58 ± 0.16 | 0.090 ± 0.054 |
| Female | 3.27 ± 0.19 | 0.00032 ± 0.0013 | 0.089 ± 0.046 | 0.50 ± 0.56 | 0.041 ± 0.050 | |
| ALN WT | ||||||
| Male | 3.01 ± 0.37 | 0.0026 ± 0.00024 | 0.144 ± 0.014 | 0.45 ± 0.12 | 0.088 ± 0.016 | |
| Female | 2.86 ± 0.24 | 0.0013 ± 0.00048 | 0.157 ± 0.058 | 0.46 ± 0.17 | 0.069 ± 0.022 | |
| ALN oim/oim | ||||||
| Male | 3.65 ± 0.12 | 0.035 | 0.002 ± 0.00097 | 0.158 ± 0.055 | 0.68 ± 0.19 | 0.083 ± 0.014 |
| Female | 3.05 ± 0.29 | 0.0025 ± 0.00046 | 0.153 ± 0.048 | 0.66 ± 0.39 | 0.065 ± 0.0092 | |
| ALN + Rank-Fc WT | ||||||
| Male | 2.46 ± 0.15 | 0.0024 ± 0.00023 | 0.138 ± 0.020 | 0.42 ± 0.13 | 0.054 ± 0.013 | |
| Female | 2.60 ± .423 | 0.0018 ± 0.00075 | 0.123 ± 0.033 | 0.28 ± 0.14 | 0.064 ± 0.013 | |
| ALN + Rank-Fc oim/oim | ||||||
| Male | 3.66 ± 0.18 | 0.032 | 0.0025 ± 0.00083 | 0.156 ± 0.034 | 0.71 ± 0.34 | 0.090 ± 0.021 |
| Female | 2.58 ± 0.42 | 0.0015 | 0.0033 ± 0.0012 | 0.171 ± 0.044 | 0.68 ± 0.23 | 0.10 ± 0.022 |
| Saline + Rank-Fc WT | ||||||
| Male | 2.68 ± 0.33 | 0.0023 ± 0.00068 | 0.150 ± 0.037 | 0.38 ± 0.089 | 0.064 ± 0.009 | |
| Female | 2.09 ± 0.42 | 0.0017 ± 0.00069 | 0.135 ± 0.033 | 0.31 ± 0.12 | 0.066 ± 0.013 | |
| Saline + Rank-Fc oim/oim | ||||||
| Male | 2.83 ± 0.35 | 0.0027 ± 0.0008 | 0.144 ± 0.057 | 0.52 ± I0.18 | 0.093 ± 0.037 | |
| Female | 2.61 ± 0.13 | 0.00238 ± 0.0005 | 0.155 ± 0.045 | 0.49 ± 0.26 | 0.084 ± 0.020 | |
Values are mean ± SD; *line width at half-maximum for images of FTIR imaging parameters: mineral-to-matrix (M/M), carbonate-to-mineral (C/P), crystallinity (XST), collagen maturity (CM), and acid phosphate substitution (HPO4); comparisons are untreated (saline) versus treatment, same sex, same genotype, p values shown if chi square showed significance and Kuskal-Wallis with Bonferroni correction had p < 0.05; FTIR = Fourier transform infrared; FWHM = full width half maximum; WT = wild-type; ALN = alendronate.