Table 2.

FTIR imaging heterogeneities (FWHM*) for cancellous bone

Tissue source	M/M	p value	C/P	p value	XST	p value	CM	p value	HPO4	p value
Saline WT
Male	2.86 ± 0.78		0.0043 ± 0.0013		0.128 ± 0.042		1.00 ± 0.65		0.21 ± 0.063
Female	2.82 ± 0.22		0.0034 ± 0.0002		0.145 ± 0.049		1.65 ± 1.00		0.078 ± 0.008
Saline oim/oim
Male	2.84 ± 0.088		0.0028 ± 0.00022		0.129 ± 0.017		1.16 ± 0.025		0.294 ± 0.041
Female	2.68 ± 0.83		0.0045 ± 0.0016		0.122 ± 0.051		1.11 ± 0.56		0.18 ± 0.020
Rank-Fc WT
Male	3.55 ± 1.10		0.0042 ± 0.0008		0.127 ± 0.053		0.80 ± 0.44		0.24 ± 0.099
Female	3.30 ± 0.84		0.0028 ± 0.0008		0.142 ± 0.023		0.83 ± 0.31		0.22 ± 0.028
Rank-Fc oim/oim
Male	5.36 ± 1.12	0.041	0.0046 ± 0.0005		0.119 ± 0.040		1.94 ± 0.94		0.27 ± 0.085
Female	4.43 ± 0.82		0.0034 ± 0.0014		0.144 ± 0.042		1.09 ± 0.08		0.16 ± 0.026
ALN WT
Male	3.59 ± 0.31		0.0044 ± 0.0012		0.117 ± 0.028		0.85 ± 0.60		0.19 ± 0.040
Female	3.32 ± 0.65		0.0025 ± 0.0004		0.235 ± 0.053		0.51 ± 0.26		0.17 ± 0.17
ALN oim/oim
Male	4.08 ± 1.08	0.026	0.0034 ± 0.0008		0.112 ± 0.029		0.68 ± 0.12		0.31 ± 0.074
Female	4.09 ± 0.31		0.0035 ± 0.0009		0.139 ± 0.027		1.55 ± 0.95		0.24 ± 0.057
ALN + Rank-Fc WT
Male	3.74 ± 0.19		0.0046 ± 0.0002		0.107 ± 0.006		0.68 ± 0.19		0.19 ± 0.039	0.005
Female	2.77 ± 0.64		0.0028 ± 0.0010		0.129 ± 0.033		0.49 ± 0.12		0.19 ± 0.040
ALN + Rank-Fc oim/oim
Male	5.50 ± 0.62	0.034	0.0056 ± 0.0032‡		0.121 ± 0.030		2.15 ± 0.98		0.32 ± 0.036
Female	4.12 ± 0.51		0.0041 ± 0.0012		0.117 ± 0.025		2.15 ± 0.92		0.21 ± 0.071
Saline + Rank-Fc WT
Male	2.19 ± 0.36		0.0057 ± 0.0020		0.123 ± 0.057		0.47 ± 0.077		0.19 ± 0.052
Female	2.95 ± 0.47		0.0028 ± 0.0009		0.15 ± 0.016		0.53 ± 0.36		0.11 ± 0.056
Saline + Rank-Fc oim/oim
Male	3.83 ± 1.31		0.0034 ± 0.0009		0.133 ± 0.048		1.05 ± 0.33		0.28 ± 0.063
Female	2.93 ± 0.54		0.0033 ± 0.0006		0.13 1 ± 0.049		1.18 ± 0.36		0.21 ± 0.11

Values are mean ± SD; *line width at half-maximum for images of FTIR imaging parameters: mineral-to-matrix (M/M), carbonate-to-mineral (C/P), crystallinity (XST), collagen maturity (CM), and acid phosphate substitution (HPO4); comparisons are untreated (saline) versus treatment, same sex, same genotype, p values shown if chi square showed significance and Kruskal-Wallis with Bonferroni correction had p < 0.05; FTIR = Fourier transform infrared; FWHM = full width half maximum; WT = wild-type; ALN = alendronate.