Table 2. Factors predicting the genetic variant of RNF213 associated with MMD among 352 patients with intracranial arterial stenosis.
| RNF 213 | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| present | absent | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age | 46.5 ± 12.2 | 57.4 ± 14.9 | <0.001 | 0.977 (0.956–0.999) | 0.040 | 0.980 (0.960–1.000) | 0.052 |
| Female gender | 121 (67.2%) | 149 (50.3%) | <0.001 | 1.148 (0.677–1.948) | 0.607 | ||
| Family history of MMD | 14 (7.8%) | 4 (1.4%) | <0.001 | 2.905 (0.831–10.159) | 0.095 | 2.828 (0.824–9.707) | 0.099 |
| Vascular risk factors | |||||||
| Hypertension | 85 (47.2%) | 161 (54.4%) | 0.129 | 1.226 (0.713–2.108) | 0.460 | ||
| Diabetes | 21 (11.7%) | 78 (26.4%) | <0.001 | 0.349 (0.178–0.684) | 0.002 | 0.368 (0.192–0.704) | 0.003 |
| Dyslipidemia | 51 (28.3%) | 96 (32.4%) | 0348 | 1.025 (0.585–1.795) | 0.931 | ||
| Angiographic findings | |||||||
| Distal ICA involvement | 138 (76.7%) | 91 (30.7%) | <0.001 | 1.569 (0.866–2.842) | 0.137 | ||
| Basal collaterals | 134 (74.4%) | 57 (19.3%) | <0.001 | 3.027 (1.714–5.346) | <0.001 | 3.529 (2.066–6.026) | <0.001 |
| Bilateral involvement | 128 (71.1%) | 65 (22.0%) | <0.001 | 2.625 (1.510–4.564) | 0.001 | 3.072 (1.825–5.170) | <0.001 |
| No. diagnostic criteria met* | <0.001 | ||||||
| 0 | 16 (20.0%) | 64 (80.0%) | Ref | Ref | |||
| 1 | 20 (28.6%) | 50 (71.4%) | 1.542 (0.701–3.388) | 0.281 | 1.529 (0.699–3.348) | 0.228 | |
| 2 | 41 (57.7%) | 30 (42.3%) | 4.834 (2.244–10.412) | <0.001 | 4.797 (2.236–10.289) | <0.001 | |
| All 3 | 99 (75.6%) | 32 (24.4%) | 9.753 (4.687–20.294) | <0.001 | 10.214 (4.952–21.068) | <0.001 | |
* Model 2, including age, gender, family history of MMD, vascular risk factors, and number of angiographic diagnostic criteria met.