Table 2. Comparative Incidence for Genetic Features found in G-TL and C-TL.
Percent Incidence (Frequency) | |||
---|---|---|---|
Feature | G-TL | C-TL | P-value |
Trisomy 14 | 25% (3/12) | 40% (8/20) | 0.46 |
Trisomy 15 | 67% (8/12) | 65% (13/20) | 1.00 |
Notch1 5ʹ Deletion | 31% (5/16) | 49% (49/101) | 0.28 |
Notch1 PEST Mutation | 69% (11/16) | 70% (71/101) | 1.00 |
Notch1 HD Mutation | 31% (5/16) | 15% (15/101) | 0.15 |
Ikzf1 LOH | 19% (3/16) | 27% (27/101) | 0.76 |
Ikzf1 Mutation | 56% (9/16) | 42% (42/101) | 0.29 |
Ikzf1 Mutation/Aberrant Expression | 56% (9/16) | 56% (57/101) | 1.00 |
Trp53 Mutation | 0% (0/16) | 15% (15/101) | 0.22 |
Trp53 Mutation/Null Expression | 0% (0/16) | 18% (18/101) | 0.13 |
Bcl11b LOH | 69% (11/16) | 100% (101/101) | 0.0001 * |
Pten Mutation/Null Expression | 80% (12/15) | 38% (38/101) | 0.004 * |
P values shown are from Fisher’s Exact Test, with differences significant at the 0.05 level marked (*)