Table 7. Loci with strongest P-values from admixture mapping of the Indigenous American component.
Chromosome | Odds ratio* (95% CI) | P-value | Genome-wide P-value | Chromosomal position of SNP with lowest P-value (bp) | 95% CI of chromosomal position (bp) (flanking SNPs) |
---|---|---|---|---|---|
2 | 4.48 (2.21–9.06) | 3.1 x 10−5 | 0.035 | 16,419,276 | 14,116,991 to 24,247,686 (rs10495620 to rs7600852) |
7 | 4.19 (2.07–8.47) | 6.5 x 10−5 | 0.08 | 142,922,662 | 137,890,026 to 150,455,295 (rs11761248 to rs10266177) |
*Fold-increased odds of ICP attributed to homozygosity for Indigenous American alleles at the locus, relative to zero Indigenous American alleles.
Note: genomic positions are derived from version GRCh37/hg19 of the human genome sequence.