Fig 5. Depletion of SVs among highly conserved genes.

We classified genes in deleted and duplicated regions (relative to the reference strain PS312) based on presence of protein domains as well as homology relationships with other nematodes including C. elegans. For the different homology classes, we find that predicted one-to-one orthologs with C. elegans are strongly depleted from SVs indicating the action of purifying selection. Conversely, conserved and orphan genes that are members of larger gene families are significantly enriched in SVs suggesting that similar processes that have generated different homology relationships at a cross-species level are operating on a microevolutionary level.