Fig 5. Increased body weight and decreased expansion of pro-inflammatory CD4+ T-cells from blood in Tg-HD5 rats.
(A) Body weight gain from the 6th week of age where the first antibody injections were performed. (B) Stool score from Tg-HD5 and Tg-ctrl groups. (C-E) In vitro stimulated cells obtained at different time points from the blood of Tg-HD5, Tg-ctrl and WT-littermates were assessed by ICS for the presence of pro-inflammatory cells expressing TNF (C), IL-17 (D) and IFN-γ (E). Results are expressed as percentages of CD4+ T gated cells. Values are expressed as mean±SEM. *p<0.05, **p<0.01, ***p<0.005 as determined by one-way ANOVA followed by Bonferroni post-hoc analysis.