Table 1.
AMKL (FAB M7) | Other AML subtypes | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Total | AML-BFM 98 | AML-BFM 04 | AML-BFM 98 + 04 | |||||||
N | (%) | N | (%) | N | (%) | P a | N | (%) | P b | |
Gender | ||||||||||
Male | 53 | 54.6 | 21 | 56.8 | 32 | 53.3 | 625 | 51.3 | ||
Female | 44 | 45.4 | 16 | 43.2 | 28 | 46.7 | 0.83 | 594 | 48.7 | 0.52 |
Age, years | ||||||||||
<2 | 64 | 66.0 | 24 | 64.9 | 40 | 66.7 | 241 | 19.8 | ||
2–5 | 23 | 23.7 | 6 | 16.2 | 17 | 28.3 | 170 | 13.9 | ||
≥6 | 10 | 10.3 | 7 | 18.9 | 3 | 5.0 | 0.06 | 808 | 66.3 | <0.001 |
WBC, 109/L | ||||||||||
<20 | 75 | 77.3 | 24 | 64.9 | 51 | 85.0 | 631 | 51.8 | ||
>20 | 22 | 22.7 | 13 | 35.1 | 9 | 15.0 | 0.03 | 587 | 48.2 | <0.001 |
CNS involvement | ||||||||||
No | 92 | 94.8 | 35 | 100.0 | 57 | 96.6 | 1036 | 87.6 | ||
Yes | 2 | 2.1 | – | – | 2 | 3.4 | 0.53 | 147 | 12.4 | <0.001 |
BM day 15 + 28 | ||||||||||
≤5 % of blasts | 74 | 77.9 | 24 | 66.7 | 50 | 84.7 | 815 | 71.1 | ||
>5 % of blasts | 21 | 21.1 | 12 | 33.3 | 9 | 15.3 | 0.05 | 331 | 28.9 | 0.16 |
Anamnesis | ||||||||||
<3 weeks | 38 | 41.8 | 16 | 43.2 | 22 | 36.7 | 680 | 57.2 | ||
≥3 weeks | 53 | 58.2 | 18 | 48.6 | 35 | 48.3 | 0.51 | 508 | 42.8 | 0.004 |
Allo HSCT in 1.CR | ||||||||||
Yes | 18 | 22.8 | 9 | 27.3 | 9 | 18.8 | 113 | 89.5 | ||
No | 63 | 77.8 | 24 | 72.7 | 39 | 81.3 | 0.35 | 962 | 10.5 | <0.001 |
aAML-BFM 98 vs. AML-BFM 04
bAMKL vs. other AML subtypes