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Mean plasma concentration–time curves of edoxaban (a) and the edoxaban metabolites M4 (b) and M6 (c) with and without rifampin. Edoxaban = a single oral dose of edoxaban 60 mg. Edoxaban with rifampin = 7 days of rifampin 600 mg (2 × 300 mg capsules once daily) followed by a single oral dose of edoxaban 60 mg administered concomitantly on day 7. Error bars represent standard deviations. The insets show semi-log scale plots
